The lab contains several EPR spectrometers including commercial systems manufactured by Bruker and Varian as well as home-built systems, at EPR frequencies ranging from 250 MHz to 34 GHz. Pulsed and CW EPR are available over this range. DEER capabilities are available at both 9 and 34 GHz. Liquid nitrogen and liquid helium temperature ranges are accessible for many of the resonators over this range of frequencies.
The primary focus of the laboratory is the measurement of distances between sites in biological molecules and the understanding of electron spin relaxation mechanisms.
Collaborations on these topics are invited.
|Bruker E580 X- and Q-band pulsed spectrometer, with DEER capability.||X-band spin echo systems with ELDOR and 1 ns resolution using a programmable timing unit designed by Richard Quine.|
|Multifrequency System with interchangeable L-, S-, and C-band bridges. Each bridge has CW, ESE, and Saturation recovery modes.||
X-band Saturation Recovery with locally-designed and constructed timing controller.
Multi-frequency EPR Sensitivity, G. A. Rinard, R. W. Quine, S. S. Eaton, and G. R. Eaton, in Multifrequency Electron Paramagnetic Resonance: Theory and Applications, S. K. Misra, Ed., Ch. 5.2, Wiley-VCH, 2011.
Electron Paramagnetic Resonance Imaging, G. R. Eaton and S. S. Eaton in Encyclopedia of Analytical Chemistry, R. A. Meyers, ed., John Wiley: Chichester. DOI: 10.1002/9780470027318.a9175. Published 15th March 2011
Electron Paramagnetic Resonance, G. R. Eaton and S. S. Eaton, in Characterization of Materials, E. Kaufmann, ed., John Wiley & Sons, published on-line May 2012, 10.1002/0471266965.com067.pub2, Vol 2, 1232 – 1244 (2012).
The World as Viewed by and with Unpaired Electrons, S. S. Eaton and G. R. Eaton, J. Magn. Reson. 223, 151 – 163 (2012). (invited perspectives article)
Conformational Basis for Asymmetric Seeding Barrier in Filaments of Three- and Four-repeat Tau, A. Siddiqua, Y. Luo, V. Meyer, M. A. Swanson, X. Yu, G. Wei, J. Zheng, G. R. Eaton, B. Ma, R. Nussinov, S. S. Eaton, and M. Margittai, J. Amer. Chem. Soc. 134, 10271 – 10278 (2012).
Remote Delivery of Hydroxyl Radicals via Secondary Chemistry of a Nonthermal Plasma Effluent, S. R. Plimpton, M. Gołkowski, D. G. Mitchell, C. Austin, S. S. Eaton, G. R. Eaton, C. Gołkowski, and M. Voskuil, Biotech. & Bioeng. 110, 1936-1944 (2013).
Single Mutations in Tau Modulate the Populations of Fibril Conformers through Seed Selection, V. Meyer, P. D. Dinkel, Y. Luo, X. Yu, G. Wei, J. Zheng, G. R. Eaton, G. B. Ma, R. Nussinov, S. S. Eaton, and M. Margittai, Angew. Chem. Int. Ed., 53, 1590-1593